The replisome is a complex molecular machine that carries out replication of DNA. The replisome first unwinds double stranded DNA into two single strands. For each of the resulting single strands, a new complementary sequence of DNA is synthesized. The net result is formation of two new double stranded DNA sequences that are exact copies of the original double stranded DNA sequence.In terms of structure, the replisome is composed of two replicative polymerase complexes, one of which synthesizes the leading strand, while the other synthesizes the lagging strand. The replisome is composed of a number of proteins including helicase, RFC, PCNA, gyrase/topoisomerase, SSB/RPA, primase, DNA polymerase I, RNAse H, and ligase.=============================================================Welcome to Global institute of medical sciences. A Place for Focussed and Integrated Coaching providing in depth Knowledge of medical subject preparing students to face various medical examinations with ease. A place where learning is fun. A common platform for All Medicine students who require mbbs tuitions, USMLE coaching,plab training and Medical PG Aspirants.www.mbbstuitions.comwww.usmleindia.comwww.gims-org.com
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