Join commentators Dave Micklos and Jan Witkowski for a lively discussion of DNA in the news from world-renowned Cold Spring Harbor Laboratory! BIG DOG, little dog Size differences between dogs come down to a single change in a single gene. All dogs are members of the same species, and each characteristic breed is a result of selective breeding by humans. Now, scientists have found that the extreme differences in dog size -- between say a Chihuahua and Great Dane -- are largely determined by a single change in a single gene. "A Single IGF1 Allele is a Major Determinant of Small Size in Dogs" by Nathan B. Sutter and others, Science (volume 316), April 6, 2007, pages 112-115.
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