Researchers have crafted a gene circuit that permits precise tuning of a gene's expression in a cell, an advance that should allow for more accurate analysis of the gene's role in normal and abnormal cellular function. This gene "dosing effect" is achieved by installing a negative feedback loop in the synthetic gene circuit, a concept similar to signal distortion control in electronics, a team led by scientists at The University of Texas MD Anderson Cancer Center reports this week in the Online Early Edition of the Proceedings of the National Academy of Sciences. See original news release: http://bit.ly/K1FuZZ
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