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Mike Levine (UC Berkeley) Part 2: Transcriptional Precision: Shadow Enhancers

http://www.ibioseminars.org/lectures/dev-bio-a-evolution/mike-levine.htmlIn Parts 2 and 3, Levine describes mechanisms used in the embryos tomaintain the precision and robustness of gene expression. One mechanismis "shadow enhancers". These are secondary enhancers found at a significantdistance from the transcription start site that act in conjunction with primaryenhancers to ensure the sharp patterns and reproducibility of gene expression. Asecond mechanism of ensuring precise activation of gene expression is "PausedPolymerase". Active RNA polymerase II binds to the transcription start site, makesa very short nascent transcript and then pauses. When activators bind to thepromoter, pol II is ready to go and is rapidly activated across many nuclei. Whenused together, shadow enhancers and paused pol II provide rapid, uniform, robustand reproducible gene activation.In the fourth part of his talk, Levine focuses on the role of repressors inregulating gene expression. He shows data from his lab that explain the mechanismof action of the Snail and Polycomb repressors.
Length: 21:52

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