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J. Michael Bishop (UCSF) Part 1: Forging a genetic paradigm for cancer

http://www.ibioseminars.org/lectures/cell-bio-a-med/j-michael-bishop.html Bishop begins his lecture with a historical review of the experiments that resulted in the realization that cancer has a genetic basis. He explains that mutations can cause normal cellular genes known as proto-oncogenes to become oncogenes, analogous to jammed accelerators causing uncontrolled cell division. Alternatively, mutations in tumor suppressor genes are analogous to a failed brake system. An accumulation of both types of mutation leads to the development of cancer.
Length: 28:37

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