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Ron Vale (UCSF) Part 3: Mining the Genome for Mitotic Treasures with English Subtitles

http://www.ibioseminars.org/lectures/bio-mechanisms/ron-vale.html The third (last) part of the lecture is on mitosis, the process by which chromosomes are aligned and then segregated during cell division. I will describe our efforts to find new proteins that are important for mitosis through a high throughput RNAi screen. I will discuss how we technically executed the screen and then focus on new proteins that are we discovered that are involved in generating the microtubules that compose the mitotic spindle. I also discuss the medical importance of studying mitosis, including the development of drugs targeted to mitotic motor proteins, which are currently undergoing testing in clinical trials.
Length: 33:41

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