http://www.ibioseminars.org/index.php?option=com_content&view=article&id=713&Itemid=707 What are the signals that tell a primordial germ cell when to migrate, where to migrate and when to stop? Lehmann addresses these questions in Part 3 by using fluoresently labeled PGCs to reveal the patterns of migration during embryogenesis. In Drosophila, Lehmann identifies several genes responsible for regulating PGC migration including tre1, which encodes a G protein coupled receptor and is required for early germ cell polarization.
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