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Mary Beckerle (University of Utah) Part 3: Focal Adhesions as Stress Sensors

http://www.ibioseminars.org/lectures/cell-bio-a-med/mary-c-beckerle.html In the third segment of my seminar, I address a new frontier in cell biology, that is how cells respond to mechanical information. Cells and tissues are exposed to physical forces in vivo and excessive mechanical stress leads to a variety of pathological consequences. I describe a system for exposing cells to controlled mechanical stress and discuss the stretch response. We have discovered that the focal adhesion protein, zyxin, is exquisitely sensitive to mechanical stimulation and is required for the ability of cells to reinforce the actin cytoskeleton when challenged by exposure to cyclic stretch. See more at http://www.ibioseminars.org
Length: 30:57

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