While this can be a tougher process, it is definitely possible. Firstly, I would recommend you getting a list of strong references that can back you up. By "strong" I mean that they know your work ethic and education well and would be able to back to you for whatever position(s) you are applying to. Having a strong reference backing is invaluable to your credibility.
Next, I would focus on writing a resume that would be able to reflect these references, as well as any relevant training/education you have had. I would expect any potential employer to inquire about a lack of degree or college education if the job typically calls for it. As long as you are able to explain to the interviewer that your education is adequate in performing the job/tasks, and you have references that can back up your statements (again, major emphasis on reliable references), you should be in good shape.
Now, there may be employers out there that may not even consider applicants without a formal college education, but that's just how some companies may be and will have to be something that you live with. Don't let this be discouraging, however, because any company that highly values growth and its employees will be able to see that you can perform the work despite your background. I hope this helps and I wish you the best of luck!